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One case of serotonin syndrome has been reported which is thought to have been precipitated by the mix of venlafaxine and trazodone (the active component consisted of in Desyrel) [Ref] Almost all selective serotonin reuptake inhibitors, mixed serotonin/norepinephrine reuptake inhibitors, as well as tricyclic antidepressants create sleep irregularities to some degree.